Fig. 1

Histology and immunohistochemistry of primary patient-derived meningiomas(tumors) (PPDT)/primary tumors and corresponding 2D and 3D models – Representative images. 3D models were incubated for 3 months. Representative images of magnetic resonance images (T1-weighted) of the primary tumors can be seen to the left (See Table 1 for clinicopathological characteristics). 3D BF: 3D brightfield, the field of view (circle) is 1 mm/1000 µm in diameter – used to estimate 3D model diameters. PPDT: primary patient-derived tumor, 2D: monolayer cell model embedded in fibrin clots, 3D: 3D models embedded in fibrin clots H&E: Hematoxylin and Eosin, EMA: Epithelial membrane antigen, PR: Progesterone receptor, Ki-67: Proliferation, SSTR2: Somatostatin receptor 2, GFAP: Glial fibrillary acidic protein. Black scale bars: All histology slides: 100 \(\:{\upmu\:}\)m